pentobarbital will minimize the level or result of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Potent or reasonable CYP3A4 inducers may increase amount of diazepam elimination; as a result, efficacy of diazepam can be diminished.pentobarbital will reduce the extent or outcome of estrogens ester